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Pipeline

Development Programs – Solid Tumor

Drug

Indication

Phase 1

Phase 2

Phase 3


BGB-24714 (SMAC Mimetic) +/- Chemotherapy

Advanced Solid Tumors

BGB-3245

(BRAF inhibitor)
Advanced solid tumors with BRAF mutations

BGB-B167 (CEA-4-1BB bispecific antibody) +/- Tislelizumab

(anti-PD-1)
Advanced solid tumors

BGB-B167 +/- Tislelizumab

Advanced or metastatic solid tumors

BGB-A445 (anti-OX40) +/- Tislelizumab

Select advanced solid tumors

BGB-A445 + Tislelizumab

Select advanced solid tumors

LBL-007 (anti-LAG-3) +/- Tislelizumab + Bevacizumab + Capecitabine*

Maintenance in unresectable or metastatic MSS/mismatch repair proficient CRC

Lifirafenib (RAF inhibitor) + Mirdametinib

(MEK inhibitor)
Advanced solid tumors

Ociperlimab (anti-TIGIT) + Tislelizumab

1L PD-L1 high advanced NSCLC

2L PD-L1+ advanced ESCC

2L + cervical cancer

Advanced solid tumors

Ociperlimab + Tislelizumab + BAT1706

(anti-VEGF)
1L HCC

Ociperlimab + Tislelizumab + Chemotherapy

1L NSCLC

Ociperlimab + Tislelizumab + Concurrent Chemoradiotherapy

Previously untreated, stage III unresectable NSCLC

Previously untreated LS-SCLC

Pamiparib

(PARP 1/2 inhibitor)
2L/3L maintenance platinum-sensitive OC

Advanced OC and TNBC

Pamiparib + Temozolomide

Advanced solid tumors

Tislelizumab

1L HCC

2L/3L NSCLC

1L MSI-H or dMMR CRC

Previously treated advanced MSI-high or dMMR solid tumors

Tislelizumab +/- Surzebiclimab (anti-TIM-3) +/- LBL-007*

Advanced solid tumors

Tislelizumab +/- Ociperlimab +/- LBL-007*

Resectable stage II/IIIA NSCLC

Tislelizumab +/- BGB-A445 +/- LBL-007 +/- Chemotherapy*

1L advanced, unresectable, or metastatic NSCLC

Tislelizumab + BGB-10188

(PI3Kδ inhibitor)
Advanced solid tumors

Tislelizumab + BGB-15025

(HPK1 inhibitor)
Advanced solid tumors

Tislelizumab + Chemoradiotherapy

Localized ESCC

Tislelizumab + Chemotherapy/ Chemoradiotherapy

Resectable ESCC

Tislelizumab + Chemotherapy

1L advanced ESCC

1L GC/GEJC

Resectable stage II or IIIA NSCLC

1L advanced nasopharyngeal cancer

1L squamous NSCLC

1L non-squamous NSCLC

1L advanced UBC

1L ES-SCLC

Tislelizumab + DKN-01 (anti-DKK1) + Chemotherapy*

1L/2L GC/GEJC

Tislelizumab + Fruquintinib

(VEGFR inhibitor)
Advanced GC/GEJC, CRC, and NSCLC

Advanced triple negative BC, EC, and CRC

Tislelizumab + Lenvatinib

(VEGFR kinase inhibitor)
1L HCC

Advanced solid tumors

Tislelizumab + Sitravatinib

(multikinase inhibitor)
Advanced NSCLC after anti-PD-(L)1 therapy

Advanced GC/GEJC/HCC

HCC post resection

Advanced ESCC after anti-PD-(L)1 therapy

Tislelizumab + Surufatinib

(VEGFR, FGFR, CSF-1R inhibitor)
Advanced solid tumors

Zanidatamab

(anti-HER2 bi-specific antibody)
2L+ HER2+ BTC

Zanidatamab + Chemotherapy +/- Tislelizumab

1L HER2+ BC and 1L HER2+ GC/GEJC

1L HER2+ advanced/metastatic GC/EC

Australia, S. Korea, US
Australia, China
Australia, US
China
China, S. Korea
China, S.Korea, Thailand
China, Thailand
Coming Soon
United States
Worldwide

BC, breast cancer; BRAF, B-Raf proto-oncogene; BRCA+, breast cancer susceptibility gene-positive; BTC, biliary tract cancer; dMMR, deficient mismatch repair; ESCC, esophageal squamous cell carcinoma; ES-SCLC; extensive-stage small cell lung cancer; GBM, glioblastoma multiforme; GC, gastric cancer; GEJC, gastroesophageal junction carcinoma; HCC, hepatocelluar carcinoma; HER2-, human epidermal growth factor receptor-2–negative; HER2+, human epidermal growth factor receptor-2–positive; MSI, microsatellite instability; NSCLC, non-small cell lung cancer; OC, ovarian cancer; R/R, recurrent/refractory; SCLC, small lung cell cancer; TNBC, triple-negative breast cancer; UBC, urothelial bladder cancer.

Development Programs – Hematology

Drug

Indication

Phase 1

Phase 2

Phase 3


Tislelizumab

(anti-PD-1)
R/R cHL

R/R cHL

BGB-10188 +/- Zanubrutinib

B-cell malignancies

BGB-11417 monotherapy

(Bcl-2 inhibitor)
B-cell malignancies

R/R CLL/SLL

R/R MCL

BGB-11417 + Azacitidine +/- Posaconazole

Myeloid malignancies

BGB-11417 + Dexamethasone +/- Carfilzomib

R/R multiple myeloma with t(11;14)

BGB-11417 monotherapy + zanubrutinib

B-cell malignancies

BGB-16673

(BTK-targeted CDAC)
B-cell malignancies

B-cell malignancies

Ociperlimab (anti-TIGIT) +/- Tislelizumab or Rituximab

R/R DLBCL

Zandelisib +/- Zanubrutinib or Rituximab*

CLL/SLL and B-cell NHL

Zanubrutinib

R/R DLBCL with CD79B

Previously treated B-cell malignancies

B-cell malignancies

Bioavailability of zanubrutinib tablets vs capsules in healthy volunteers

Zanubrutinib + Lenalidomide +/- Rituximab

R/R DLBCL

Zanubrutinib + Obinutuzumab

R/R FL

Zanubrutinib + Rituximab

1L MCL

R/R MZL

Zanubrutinib +/- Venetoclax

1L CLL/SLL

Australia, China
Australia, US
China
Japan
Switzerland, US
United States
Worldwide

* In collaboration with MEI Pharma
This combination is being studied in the third cohort of NCT03336333

CDAC chimeric degradation activating compound; B-cell NHL, B-cell non-Hodgkins lymphoma; cHL, classical Hodgkin lymphoma; CLL, chronic lymphotic leukemia; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; GCB, germinal center B cell-like; MCL, mantle cell lymphoma; MZL, marginal zone lymphoma; NHL, non-Hodgkin lymphoma; NK, natural killer; R/R, recurrent/refractory; SLL, small lymphocytic lymphoma; WM, Waldenstrӧm macroglobulinemia.

Videos

PARPI Mechanism of Action

Anti-PD-1 Mechanism of Action

BTKI Mechanism of Action

Anti-TIGIT Mechanism of Action